![]() ![]() ![]() ![]() For preparing 900 mg of ointment, 90 mg of mechlorethamine is mixed with 10 ml of absolute alcohol and sufficient xipamide (Aquaphor). The solution is prepared by mixing 10 mg of mechlorethamine with 50 ml of tap water. Mechlorethamine (Mustargen) can be applied on the skin as an aqueous solution or an ointment base. As a basis of experimental studies dogs were treated with CCNU (50 mg/m2 given orally every 3 weeks). Studies have indicated that pegylated-liposomal doxorubicin (Doxil) has produced remissions. Prednisone may also be useful in controlling pruritus. However, remissions are not long-standing. Retinoids, (chemical compounds related to Vitamin A) like isotretinoin (Accutane) and etretinate (Tegison) have yielded gratifying results in canine T-cell cutaneous lymphoma.Ī combination of polyethylene glycol (PEG)-L-asparaginase, (30mg/kg given intramuscularly weekly) have proved to be effective on dogs with cutaneous T-cell lymphoma. Diffuse non-T-cell lymphoma is best treated with combination chemotherapy. Fractionated radiotherapy has been associated with long term control. Solitary lesions may be treated with surgical excision or radiation therapy. The treatment of cutaneous lymphoma depends on the extent of the disease. Staging procedures vary and stage does not hold any prognostic importance. There may also be oral involvement that can appear as multicentric erythematous, plaque like lesions or nodules on the gums and lips.ĭiagnostic technique and clinical staging-įor cutaneous lymphoma, punch biopsies (3-4mm) should be taken from the most representative and infiltrated, but not infected skin lesions. As the disease advances the skin becomes more erythematous, thickened, ulcerated, and exudative (relating to the oozing of fluid). In the early phases scaling, alopecia (loss of hair), and pruritus (itching) are seen. They appear as ulcers, nodules, plaques, ulcers, and erythremic or exfoliative dermatitis. It originates in the skin and can take the form of reddened lumps that can be itchy at times and also cause extreme discomfiture in dogs. Dogs suffering from mediastinal lymphoma encounter respiratory distress, polydipsia, polyuria, pitting edema of the head, necks and forelimbs. It is typically characterized by enlargement of the cranial mediastinal lymph nodes, thymus, or both. This form of lymphoma comprises only a fraction of all cases of lymphosarcomas. If left untreated, they can restrict the function of lungs, resulting in death. They are present around the cardiothoracic region. Mediastinal lymphoma in dogs usually develops in the lymphoid tissues of the chest. ![]()
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